Gamma Scintigraphy
Visualising formulation behaviour in man
Gamma scintigraphy is a nuclear imaging technique that allows non-invasive in vivo imaging of gamma-emitting radioisotopes.
By incorporating a small amount of a radiopharmaceutical into a
dosage form and administering it to a volunteer or patient, we can
follow the fate of the dosage form by acquiring sequential images
with a gamma camera.
What information will it give me on my formulation?
We will radiolabel your formulation and monitor it to provide
an accurate reflection of formulation behaviour. In the oral
field, we can provide the information you require on:
- Site of disintegration
- Time of disintegration post-dose
- Gastric emptying
- Gastrointestinal transit
- In vitro-in vivo correlation
- Food effects
- Inter- and intra-subject variability
Gamma scintigraphy can also be used to investigate the residence kinetics of ophthalmic, nasal and oesophageal formulations and to study the deposition of pulmonary formulations. Conducting PK sampling in parallel with scintigraphy permits correlation of dosage form performance characteristics with plasma concentration.
We have extensive experience in designing suitable labelling techniques for new formulations and delivery systems. We would be happy to discuss other applications of this technology.
As a GMP-licensed manufacturing site, we will handle your Investigational Medicinal Product expertly to ensure regulatory compliance and the highest quality of data. We provide QP release, and our registered pharmacists will dispense the final IMP for clinical administration.
Why is gamma scintigraphy useful?
Having access to information on the in vivo performance of your formulation greatly helps in deciding the next course of action in your formulation development strategy, reducing costs and time to market.
Scintigraphic data can also be used to support drug delivery claims, for marketing or regulatory purposes.
For access to our company literature, visit our Publications page.
Gamma camera images courtesy of Siemens Healthcare
